Re: [rp-ml] Jaw Bone From Stem Cells

From: Abhishek Goel <>
Date: Mon Aug 30 2004 - 00:44:48 EEST

How does Therics play role in all this? I think this is the only company which has taken scaffold construction and application of RP to tissue engineering to next level. What say?

Brock Hinzmann <> wrote:
I think I forgot to hit reply to all on thee last message
I sent to Larry (who might forward it), but I am curious
as to how something like the Bio_plotter, which I saw they
people at Envisiontec playing around with, could be used
to build structures with the stem cells encapsulated in
chambers in just the right way they need to become this
type of tissue or that. Even better if the structural
material then biodegrades and goes away, once the tissue

Anyway, I am sure a lot of science on stem cells still has
to be done, but if it turns out to be a case of structure
dictating function, it might not take very long to see
practical applications.


On Fri, 27 Aug 2004 16:41:37 -0500
"David K. Leigh" wrote:
>Early work at the Univ. of Texas using the SLS process
>worked on these types
>of projects. And, as I recall, they were able to implant
>an RP jawbone into
>a monkey with limited success. The body started adapting
>to it and
>depositing calcium on the matrix. There was more work
>done on a
>bio-material, but I'm not sure what ever happened. I
>think the original
>work was done with less than full density polycarbonate.
>David K. Leigh (254)933-1000
>Harvest Technologies fax(254)298-0125
>Rapid Prototyping Services
>-----Original Message-----
>From: Blasch, Larry []
>Sent: Friday, August 27, 2004 3:35 PM
>To: 'Brock Hinzmann';
>Subject: RE: [rp-ml] Jaw Bone From Stem Cells
>I didn't read it until you pointed it out but you are
>right, a z-corp with
>hydroxyapatite cement see link -->
> might
>allow you to build
>the bone and implant the marrow stem cells to get the
>bone growth process
>started again.
>For a full description of the back implant/boon growth
>procedure check out
>Larry Blasch
>-----Original Message-----
>From: Brock Hinzmann []
>Sent: Friday, August 27, 2004 2:10 PM
>Subject: Re: [rp-ml] Jaw Bone From Stem Cells
>AP wire story out of London reports on a paper in this
>week's Lancet medical journal that doctors in Kiel,
>Germany, were able to grow in a man's back, from stem
>cells, a replacement lower jaw bone that had been lost to
>cancer, which they then surgically removed from his back
>and reinserted into its proper place. The jaw bone was
>grown in a titanium cage implant.
>It seems to me that the Bio-plotter or something similar
>should be capable of forming the templates in which to
>grow tissues from stem cells. Research at Northwestern
>University suggests stem cells are triggered to grow into
>different types of tissues by the manner in which they
>physically confined. As the nature of which type of
>confinement produces which type of tissue is discovered,
>perhaps simple 3-D plotters could shape any tissue to
>custom dimensions. Even if the doctors remained
>constrained to growing custom bone implants in tantanium
>cages, it seems like RP&M should play a role in creating
>the custom titanium forms. Anyone on the rp-ml involved
>any aspect of this development?
>Brock Hinzmann
>Technology Navigator
>SRI Consulting Business Intelligence
>+1 (650) 859-4350

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Received on Sun Aug 29 23:57:31 2004

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